The unit develops, evaluates, and translationally applies pharmacological strategies targeting gastrointestinal and immune-mediated diseases. We integrate preclinical research, translational investigation, and clinical pharmacology to advance innovative therapeutic approaches for disorders of the gut and immune system, combining mechanistic studies, pharmacodynamic and pharmacogenetic investigations, biomarker identification, and therapeutic drug monitoring.
Research units
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Gastrointestinal & Immunopharmacology Unit
Gastrointestinal & Immunopharmacology Unit
4 researchers
Research areas
Purinergic signaling in GI inflammation
ATP-adenosine axis in intestinal inflammation, mucosal immunity, and gut homeostasis; relevance in IBD, celiac disease, and functional GI disorders.
Neuro-immune interactions in GI disorders
Pharmacological modulation of enteric nervous system and immune crosstalk in IBD, IBS, postoperative ileus, and dysmotility syndromes.
Intestinal barrier function
Tight junction regulation, epithelial regeneration, hypoxia signaling, and inflammatory mediators driving barrier resilience and mucosal repair.
Immunopharmacology and precision medicine
Pharmacodynamic and pharmacogenetic studies to personalize therapy with biologics, small molecules, and emerging immunomodulators.
Recent publications
Team
Prof. Luca Antonioli
PhD · Co-PI
Prof. Matteo Fornai
PhD · Co-PI
Clelia Di Salvo
PharmD
Giulia Valdiserra
PharmD